Sunstone Life Science Fund II portfolio company Orphazyme ApS, a Danish biotech company developing novel therapies for the treatment of protein misfolding diseases, has announced the completion of enrolment for its lead program within Niemann-Pick type C disease. Niemann-Pick type C disease (NPC) is one of several fatal lysosomal storage diseases and is affecting around 1 in 150,000 newborns. Although symptom onset and progression is highly variable, NPC is most often diagnosed in childhood and adolescence. Impaired breakdown and recycling of lipids in cells of affected individuals leads to malfunction and demise of cells in the brain and other organs, which results in seizures, progressive loss of muscle control and intellectual capacity.